"Nucleic acid drugs" faʻaaogaina le "nucleic acid," e faʻasino i mea e pei ole DNA ma RNA e pulea faʻamatalaga faʻavae, o vailaʻau.O nei mea e faʻatagaina ai le faʻaogaina o molelaʻau e pei o le mRNA ma le miRNA e le mafai ona faʻatatau i vailaʻau faʻamaʻi maualalo mole mamafa ma vailaʻau antibody, ma o loʻo i ai se faʻamoemoega tele mo nei vailaʻau e avea ma vailaʻau o loʻo sosoo ai.O su'esu'ega malosi o lo'o fa'atinoina i le lalolagi atoa aua o lo'o fa'amoemoe e ta'ita'i atu ai i le fa'atupuina o vaila'au sa le'i mafai ona fa'ata'atia muamua.
I le isi itu, ua faʻailoa mai o le atinaʻeina o vailaʻau nucleic acid e iai faʻafitauli e foia, e aofia ai le "(i) le mautu o molelaʻau nucleic acid i totonu o le tino," "(ii) atugaluga mo faʻafitauli leaga o vailaʻau," ma le "(iii) faigata i le faʻaogaina o vailaʻau (DDS)."E le gata i lea, o kamupani Iapani o loʻo laa i tua i le atinaʻeina o vailaʻau nucleic acid ona o le puleaina o pateni iloga o le nucleic acid e kamupani i Europa ma le US, ma mafua ai le faʻalavelave i le atinaʻeina o Iapani.
Uiga o vailaau nucleic acid
"Nucleic acid drugs" o se isi augatupulaga e su'esu'e ai vaila'au fa'atekonolosi fa'atasi ai ma se faiga e matua'i ese lava le fa'atinoga nai lo vaila'au masani.O lo'o fa'aalia ai fo'i le agava'a e gaosia fa'afaigofie i mole mole lapopo'a ma le ono mafai ona fa'aalia le aoga ma le saogalemu e sili atu nai lo vaila'au fa'ama'i.Ona o nei foliga, o loʻo iai le faʻamoemoega mo vailaʻau nucleic acid e faʻaaogaina i le kanesa ma faʻamaʻi faʻaleagaina lea sa faigata ona togafitia muamua, faʻapea foʻi ma faʻamaʻi e pei o le influenza ma viral infections.
Ituaiga o vailaau nucleic acid
Ole vaila'au ole nucleic acid lea e fa'aogaina ai le DNA ma le RNA e aofia ai mea e fa'atatau i nucleic acids i le tulaga lea e fa'apipi'iina ai le porotini mai le genome DNA (e pei o le mRNA ma le miRNA) ma i latou e fa'atatau i le porotini.
Ituaiga ma uiga o vailaau nucleic acid (fualaau mo le puipuia ma togafitiga)
E iai vaila'au nucleic acid e eseese ituaiga ma uiga e tusa ai ma fa'amoemoega ma faiga o gaioiga.
| Ituaiga | Sini | Nofoaga o gaioiga | Faiga o gaioiga | Aotelega |
| siRNA | mRNA | I totonu o le sela (cytoplasm) | mRNA vaeluaga | RNA fa'alua fa'atasi ma cleavage o mRNA fa'atasi i lefa'asologa (siRNA), pine fa'auluulu tasi-stranded RNA (shRNA), ma isi.ma le aoga e tusa ai ma le mataupu faavae o le RNAi |
| miRNA | microRNA | I totonu o le sela (cytoplasm) | sui microRNA | RNA fa'alua, miRNA o le RNA fa'aulu lauulu tasipo'o lona fa'atusa e fa'aaogaina e fa'amalosia ai le galuega a le miRNA ua fa'aleagainae fa'aletonu |
| Antisense | mRNA miRNA | I totonu o le sela (i totonu o le nucleus, cytoplasm) | mRNA ma le miRNA faʻaleagaina, faʻalavelave faʻapipiʻi | RNA/DNA fa'afuafua tasi lea e fusifusia i le mRNA fa'amoemoema le miRNA e mafua ai le faʻaleagaina poʻo le faʻalavelave,po'o le fa'agaoioiga e fa'amisi exon pe a fa'apipi'i |
| Aptamera | Polotini (porotini faaopoopo) | I fafo o le sela | Fa'alavelave fa'atino | RNA/DNA fa'afuafua tasi lea e fusifusia i le porotini fa'atataui se faiga tutusa i antibodies/DNA |
| Fa'ailo | Polotini (fa'ailoga fa'aliliu) | I totonu o le sela (i totonu o le nucleus) | Taofi fa'aliliuga | DNA fa'alua fa'atasi ma fa'asologa tutusa i le nofoaga o lo'o fusifusia aimo transcription factor, lea e fusia i le transcription factoro le kenera ua afaina e taofia ai le kenele taula'i |
| Ribozyme | RNA | I totonu o le sela (cytoplasm) | RNA vaeluaga | RNA fa'afuafua e tasi ma le fa'aogaina o le enzyme mo le fusifusia ma le vaeluagao le RNA taulaʻi |
| CpG oligo | Polotini (receptor) | Laupapa sela | Immunopotentiation | Oligodeoxynucleotide fa'atasi ma le CpG motif (DNA fa'asolo tasi) |
| Isi | - | - | - | Nucleic acid fualaaus e ese mai i latou o loʻo lisi atu i luga lea e galue aifa'agaoioi le puipuiga fa'anatura, pei ole PolyI:PolyC (RNA fa'alua fa'alua)ma antigen |
Taimi meli: Iul-25-2023
